Forensic Context

A study in humans identified the miR-660-3p as downregulated in the whole blood of patients with recurrent myocardial infarction after percutaneous coronary intervention, with this differential expression remaining significant after false-discovery rate correction [Onuoha et al. DOI:10.1111/cts.13307]. A study in humans demonstrated that the miR-660-3p is a high diagnostic performance circulating microRNA for acute myocardial infarction (AMI), showing a low level in healthy plasma and robust diagnostic performance as part of a final two-miRNA panel [Wang et al. DOI:10.1186/s40364-024-00690-x]. Separately, research in humans analyzing blood samples from monozygotic twins identified miR-660-5p, a related but distinct isoform, as differentially expressed and shared across five twin pairs, suggesting a potential role for microRNA expression profiles in forensic identification [Xiao et al. DOI:10.1016/j.fsigen.2019.05.003].