Forensic Context

A study in human patients with heart failure after acute myocardial infarction demonstrated that the miR-660-5p was investigated as a potential biomarker for sacubitril/valsartan resistance, but its expression change was not consistent with initial microarray data during subsequent qRT-PCR validation in 18 patient sample pairs [Su et al. DOI:10.1016/j.ejphar.2023.175547]. A study in humans demonstrated that the miR-660-5p is a differentially expressed microRNA shared across five pairs of monozygotic twins, indicating its potential as a biomarker for distinguishing genetically identical individuals in forensic identification [Xiao et al. DOI:10.1016/j.fsigen.2019.05.003].