Basic Information

Symbol
hsa-mir-661
RNA class
miRNA miRNA hairpin
Alias
MIR661 MicroRNA 661 Hsa-Mir-661 Hsa-MiR-661 MIRN661 MIMAT0003324 MI0003669
Location (GRCh38)
8:143945191-143945279
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification Wound age identification Other applications
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-661
Sequence length
89 nt
GC content
0.6966

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-49.30 kcal/mol
Thermodynamic ensemble
Free energy: -49.73 kcal/mol
Frequency: 0.4954
Diversity: 2.87
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
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Forensic Context

A review of human studies identified 197 miRNAs associated with wound healing, burn wound healing, and scarring, with specific miRNAs like the mir-661 showing altered expression in human skin tissue post-burn and in hypertrophic scar tissue compared to normal skin [Siu et al. DOI:10.1111/wrr.13100]. A separate forensic study in humans established a decision algorithm using four miRNAs, including hsa-miR-891a-5p for semen and hsa-miR-144-3p for blood, which correctly identified 9 out of 10 blinded body fluid samples and was effective on aged specimens [Sauer et al. DOI:10.1016/j.fsigen.2016.01.018]. A study in humans demonstrated that mir-661 was identified as a potential target of exo-circ-0020887 and exo-circ-0009590 through bioinformatics prediction [Wang et al. DOI:10.1515/med-2023-0807].