Basic Information

Symbol
hsa-mir-663a
RNA class
miRNA miRNA hairpin
Alias
MIR663A MicroRNA 663a Hsa-MiR-663a Hsa-Mir-663 MiR-663a MicroRNA 663 MIRN663 MIR663 Hsa-Mir-663a MIMAT0003326 MI0003672
Location (GRCh38)
20:26208186-26208278
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Wound age identification
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-663a
Sequence length
93 nt
GC content
0.7634

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-50.50 kcal/mol
Thermodynamic ensemble
Free energy: -52.38 kcal/mol
Frequency: 0.0470
Diversity: 15.45
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
....((((.((((((((.((.(((((((((((((((((........).))))).....)))))))).))).))..))))).))))))).....
Thermodynamic Ensemble Prediction
....((((.((((((((.((.(((((((((((((((({,{,.....}.))}))}}}..))))))))},)).))..))))).))))))).....
Forensic Context

A review of human studies identified the mir-663a as upregulated two days post-burn in deep partial thickness burn skin compared to normal skin [Siu et al. DOI:10.1111/wrr.13100]. A study in mice demonstrated that the mir-663a controls the TGF-β1 signaling pathway, where its downregulation upregulates TGF-β1 expression to activate the TGF-β1/Smad pathway, facilitating re-epithelialization and granulation tissue production during wound healing [Wang et al. DOI:10.1007/s00438-024-02183-w].