Basic Information
Symbol
hsa-miR-663a
RNA class
miRNA
mature miRNA
Alias
hsa-miR-663a
MIR663A
MicroRNA 663a
Location (GRCh38)
-
Forensic tag(s)
Mechanical injury analysis
Wound age identification
External database
Sequence & Structure
Secondary Structure
Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-50.50 kcal/mol
Thermodynamic ensemble
Free energy:
-52.38 kcal/mol
Frequency:
0.0470
Diversity:
15.45
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
....((((.((((((((.((.(((((((((((((((((........).))))).....)))))))).))).))..))))).))))))).....
Thermodynamic Ensemble Prediction
....((((.((((((((.((.(((((((((((((((({,{,.....}.))}))}}}..))))))))},)).))..))))).))))))).....
Forensic Context
A review of human studies identified the miR-663a as upregulated two days post-burn in deep partial thickness burn skin compared to normal skin [Siu et al. DOI:10.1111/wrr.13100]. A study in mice demonstrated that the miR-663a controls the TGF-β1 signaling pathway, where its downregulation upregulates TGF-β1 expression to activate the TGF-β1/Smad pathway, facilitating re-epithelialization and granulation tissue production during wound healing [Wang et al. DOI:10.1007/s00438-024-02183-w].