Basic Information

Symbol
hsa-miR-665
RNA class
miRNA mature miRNA
Alias
hsa-miR-665 MIR665 MicroRNA 665
Location (GRCh38)
-
Forensic tag(s)
Mechanical injury analysis
External database
miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-miR-665
Sequence length
20 nt
GC content
0.7000

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-34.10 kcal/mol
Thermodynamic ensemble
Free energy: -35.75 kcal/mol
Frequency: 0.0690
Diversity: 6.61
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(.(((.((((((((((.((((((...(((((....))).))....)))))).))))))))))..))).)..
Thermodynamic Ensemble Prediction
,(.(((.((((((((((.((((((...{{{({.....}}.})....)))))).))))))))))..))).),.
Forensic Context

A study in mice demonstrated that the miR-665 is significantly upregulated in the traumatized cortex following controlled cortical impact-induced traumatic brain injury, being listed among the 50 most up-regulated miRNAs [Meissner et al. DOI:10.1089/neu.2015.4077]. In rhesus macaques subjected to whole thorax irradiation, the miR-665 was identified as a key feature in a predictive model for the future development of pleural effusion, achieving 100% accuracy in forecasting this complication at Day 21 post-exposure [May et al. DOI:10.1038/s41598-022-16316-x]. In a separate study in rats, the miR-665 was downregulated in plantaris muscle tissue in response to hindlimb unloading [Song et al. DOI:10.1097/BCR.0000000000000444].