Forensic Context

A study in human cardiac stromal cells from arrhythmogenic cardiomyopathy patients identified the miR-671-3p as having a tendency for differential expression following PKP2 knockdown, though this did not reach statistical significance [Rainer et al. DOI:10.1186/s12864-018-4876-6]. In a separate human study, plasma analysis of coronary artery disease patients found the miR-671-3p was significantly downregulated and validated by qRT-PCR, demonstrating diagnostic utility with an AUC of 0.739 in ROC analysis [Zhong et al. DOI:10.1002/jcla.23020]. In a separate review of traumatic brain injury, the miR-671-3p was identified as a serum microRNA upregulated in mouse serum at 3 hours post-mild traumatic brain injury across injury severities, though this specific application was mentioned in introductory discussion and not experimentally studied within that paper [Martinez & Peplow DOI:10.4103/1673-5374.219025].