Basic Information

Symbol
hsa-mir-6729
RNA class
miRNA miRNA hairpin
Alias
MIR6729 MicroRNA 6729 Hsa-Mir-6729 MicroRNA Mir-6729 MIMAT0027360 MIMAT0027359 MI0022574
Location (GRCh38)
1:12029158-12029222
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-6729
Sequence length
65 nt
GC content
0.7538

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-41.40 kcal/mol
Thermodynamic ensemble
Free energy: -42.05 kcal/mol
Frequency: 0.3510
Diversity: 6.25
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
..(((.(((((((((.((.(((((((((.........)))).))))).))))))))))).)))..
Thermodynamic Ensemble Prediction
,,(((.(((((((((.((.(((((((({,........)))).))))).))))))))))).)))..
Forensic Context

A study in humans identified the mir-6729-3p as a biomarker for recurrent myocardial infarction risk, finding it was downregulated in the whole blood of patients with recurrent MI after percutaneous coronary intervention, with this differential expression remaining significant after false-discovery rate correction in a replication cohort, though it was not significantly different in plasma samples [Onuoha et al. DOI:10.1111/cts.13307]. Another human study investigating postmortem-derived exosomal miRNAs for acute myocardial infarction diagnosis found the mir-6729-3p was significantly decreased in plasma-derived exosomes from the MI group compared to controls in next-generation sequencing analysis [Kim et al. DOI:10.3390/ijms25179619].