Forensic Context

A study in humans identified the miR-6729-3p as a biomarker for recurrent myocardial infarction risk, finding it was downregulated in the whole blood of patients with recurrent MI after percutaneous coronary intervention, with this differential expression remaining significant after false-discovery rate correction in a replication cohort, though it was not significantly different in plasma samples [Onuoha et al. DOI:10.1111/cts.13307]. Another human study investigating postmortem-derived exosomal miRNAs for acute myocardial infarction diagnosis found the miR-6729-3p was significantly decreased in plasma-derived exosomes from the MI group compared to controls in next-generation sequencing analysis [Kim et al. DOI:10.3390/ijms25179619].