Forensic Context

A study in humans with coronary artery disease demonstrated that the mir-6771-3p was downregulated in whole blood of patients with recurrent myocardial infarction after percutaneous coronary intervention, with this differential expression remaining significant after false-discovery rate correction (FDR <0.1) in a replication cohort [Onuoha et al. DOI:10.1111/cts.13307]. The investigation found no significant differential expression for the mir-6771-3p in plasma samples, and the research indicated that whole blood may be the preferred sample source for miRNA profiling related to thrombotic risk prognosis.