Basic Information

Symbol
hsa-mir-6875
RNA class
miRNA miRNA hairpin
Alias
MIR6875 MicroRNA 6875 Hsa-Mir-6875 MicroRNA Mir-6875 MIMAT0027650 MIMAT0027651 MI0022722
Location (GRCh38)
7:100868036-100868107
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-6875
Sequence length
72 nt
GC content
0.5694

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-29.90 kcal/mol
Thermodynamic ensemble
Free energy: -31.26 kcal/mol
Frequency: 0.1105
Diversity: 5.00
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
....((((((((.(((((.((((((((.((..((....))..)).))).))))).))))).))...))))))
Thermodynamic Ensemble Prediction
....((((((((.(((((.((((((((.((..((....))..)).)))}})))).))))).)),..})))))
Forensic Context

A review of human studies identified 197 miRNAs associated with wound healing, burn wound healing, and scarring, with specific miRNAs like the mir-6875-5p showing altered expression in human skin tissue samples post-burn and in hypertrophic scar tissue compared to normal skin [Siu et al. DOI:10.1111/wrr.13100]. In a separate human study investigating coronary artery disease, next-generation miRNA sequencing of whole blood identified numerous miRNAs, including the mir-6875-5p, as differentially expressed in patients with recurrent myocardial infarction, with whole blood being a more effective sample source than plasma for such profiling [Onuoha et al. DOI:10.1111/cts.13307]. A study in humans identified the mir-6875-5p as a prognostic biomarker exhibiting an area under the curve (AUC) greater than 0.75 for overall survival prediction in acute myocardial infarction patients [Wang et al. DOI:10.1186/s40364-024-00690-x].