Basic Information

Symbol
hsa-mir-7-2
RNA class
miRNA miRNA hairpin
Alias
MIR7-2 MicroRNA 7-2 Hsa-MiR-7-2-3p Hsa-Mir-7-2 MIRN7-2 Hsa-Mir-7-P1_pre MIMAT0000252 MIMAT0004554 Hsa-MiR-7-5p MI0000264 MiR-7-5p Mir-7-2 hsa-mir-7b
Location (GRCh38)
7:128207872-128207943
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden unexpected death diagnosis Sudden cardiac death diagnosis Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-7-2
Sequence length
110 nt
GC content
0.5091

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-47.00 kcal/mol
Thermodynamic ensemble
Free energy: -48.52 kcal/mol
Frequency: 0.0854
Diversity: 5.48
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((....))).((((...(((((((.((((..((.(((((.(.(((((.(((((((............))))))))))))).))))).))..)))).))))))).)))).
Thermodynamic Ensemble Prediction
(((....))).((((...(((((((.((((..((.(((((.(.(((((((((((((............))))))))))))).))))).))..)))).))))))).)))).
Forensic Context

A study in human SIDS cases demonstrated significant upregulation of mir-7b in brainstem tissue compared to controls, establishing the feasibility of miRNA analysis in archived tissues [Courts et al. DOI:10.1016/j.forsciint.2013.02.032]. In severely injured human trauma patients, mir-7b showed a strong direct correlation with TLR3 gene expression in whole blood, indicating its role in the inflammatory response to severe injury [Uhlich et al. DOI:10.1016/j.surg.2014.06.017]. A study in mice demonstrated that miR-7b-5p was significantly downregulated in myocardial tissue following acute myocardial infarction and was computationally predicted to target heart rate-related genes Hcn4 and Pde4d [Tuerxun et al. DOI:10.1007/s12013-024-01528-x]. In humans, plasma levels of the mir-7b were significantly upregulated in heroin-dependent patients compared to healthy controls, with a diagnostic area under the curve of 0.758, demonstrating its potential as a biomarker for substance use disorder [Liu et al. DOI:10.3389/fpsyt.2021.679206].