Basic Information

Symbol
hsa-mir-708
RNA class
miRNA miRNA hairpin
Alias
MIR708 MicroRNA 708 Hsa-MiR-708-3p Hsa-MiR-708-5p Hsa-Mir-708 MIRN708 Hsa-Mir-28-P3_pre MIMAT0004926 MIMAT0004927 MI0005543
Location (GRCh38)
X:147259652-147259726
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification Mechanical injury analysis Other applications
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-708
Sequence length
88 nt
GC content
0.4886

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-41.60 kcal/mol
Thermodynamic ensemble
Free energy: -42.67 kcal/mol
Frequency: 0.1772
Diversity: 7.53
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
..((((((((.(((((((((((.(((((.((...((..(((.......)))..)).)).))))).))))))))))).))))))))...
Thermodynamic Ensemble Prediction
..((((((((.(((((((((((.(((((.((...{(..{{{.....,.}}}...).)).))))).))))))))))).))))))))...
Forensic Context

A review of human studies identified 197 miRNAs associated with wound healing, burn wound healing, and scarring, with specific miRNAs showing altered expression in human skin tissue samples post-burn, during healing, and in hypertrophic scar tissue [Siu et al. DOI:10.1111/wrr.13100]. A study in rats demonstrated that the mir-708 was significantly upregulated in the dorsolateral striatum (DLS) of addiction-vulnerable animals compared to resilient controls, with no change observed in the dorsomedial striatum [Quinn et al. DOI:10.1038/Tp.2014.144]. In a separate rat model of contusion spinal cord injury, the mir-708 was found to be significantly downregulated one day post-injury [Hu et al. DOI:10.1089/neu.2012.2748].