Basic Information

Symbol
hsa-mir-744
RNA class
miRNA miRNA hairpin
Alias
MIR744 MicroRNA 744 Hsa-MiR-744-5p Hsa-MiR-744-3p Hsa-Mir-744 MIRN744 Hsa-Mir-744_pre MIMAT0004945 MIMAT0004946 MI0005559 Mir-744
Location (GRCh38)
17:12081899-12081996
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Cause of death analysis
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-744
Sequence length
98 nt
GC content
0.5408

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-36.50 kcal/mol
Thermodynamic ensemble
Free energy: -38.15 kcal/mol
Frequency: 0.0685
Diversity: 5.11
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((((.(((((..((((.((((((.(((((((...........((((((...)))))).......)))))))))).))).)))).))))).)))))..
Thermodynamic Ensemble Prediction
,((((.(((((..((((.((((((.(((((((,,......,..((((((...)))))).......)))))))))).))).)))).))))).)))),..
Forensic Context

A study in humans demonstrated that the mir-744 was upregulated 4 days post-burn in deep partial thickness burn skin compared to normal skin and was also upregulated 6 hours post-burn in heat-shocked skin epidermal stem cells versus controls [Siu et al. DOI:10.1111/wrr.13100]. A study in miniature Yucatan pigs demonstrated that the mir-744 was significantly elevated in serum after severe spinal cord injury and showed high diagnostic accuracy for differentiating severe from moderate injury (AUC = 0.98) [Tigchelaar et al. DOI:10.1038/s41598-017-01299-x]. In human postmortem cerebellar tissue, the mir-744 was identified as a hypoxia marker, and its combination with miR-138 completely discriminated individuals who died from traumatic frontal cortex injuries from a reference group who died from natural causes [Schober et al. DOI:10.1007/s00414-014-1129-3].