Forensic Context

A study in human skin tissue and cell models demonstrated that the miR-744-3p is upregulated in burn hypertrophic scar tissue versus normal skin and is also upregulated six hours post-burn in heat-shocked skin epidermal stem cells versus controls [Siu et al. DOI:10.1111/wrr.13100]. In a separate human study of coronary artery disease patients, the miR-744-3p was differentially expressed in both plasma and whole blood in an initial cohort and was associated with plaque rupture in ST elevation myocardial infarction [Onuoha et al. DOI:10.1111/cts.13307]. A study in human patients with ST-segment elevation myocardial infarction demonstrated that circulating levels of the miR-744-3p were significantly upregulated in those with plaque rupture compared to those with plaque erosion [Li et al. DOI:10.1016/j.ygeno.2020.11.019].