Basic Information

Symbol
hsa-mir-758
RNA class
miRNA miRNA hairpin
Alias
MIR758 MicroRNA 758 Hsa-Mir-758 Hsa-MiR-758-3p MIRN758 Hsa-Mir-154-P26_pre Hsa-MiR-758-5p MIMAT0022929 MIMAT0003879 MI0003757 Mir-758
Location (GRCh38)
X:152393421-152393529
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification Mechanical injury analysis Chronological age estimation
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-758
Sequence length
88 nt
GC content
0.4886

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-29.60 kcal/mol
Thermodynamic ensemble
Free energy: -31.36 kcal/mol
Frequency: 0.0573
Diversity: 7.26
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
...(((((((.((((.((((.((((((.(.(((.((((.........).))).)))..))))))).))))...)))))))))))....
Thermodynamic Ensemble Prediction
,,.(((((((.((((.((((.((((((.,.(((.((((.........),})).)))..,)))))).))))...)))))))))))..,,
Forensic Context

A review of human studies identified 197 miRNAs associated with wound healing, burn wound healing, and scarring, with specific miRNAs showing altered expression in human skin tissue samples post-burn and in hypertrophic scar tissue [Siu et al. DOI:10.1111/wrr.13100]. A study in mice demonstrated that the mir-758 was among the most up-regulated miRNAs (fold changes between 3 and 5) in the gastrocnemius muscle of young sham animals compared to adult sham animals, indicating a significant age effect on its expression [Song et al. DOI:10.1038/s41598-022-26040-1]. In a separate study in rats, rno-miR-758 was persistently up-regulated (>1.5-fold) in the hippocampus at 1, 3, and 5 days following traumatic brain injury, identifying it as a potential marker for TBI progression [Sun et al. DOI:10.1007/s11596-014-1313-1].