Basic Information

Symbol
hsa-mir-765
RNA class
miRNA miRNA hairpin
Alias
MIR765 MicroRNA 765 Hsa-Mir-765 Hsa-MiR-765 MIRN765 MIMAT0003945 MI0005116 Mir-765
Location (GRCh38)
14:101026020-101026107
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-765
Sequence length
114 nt
GC content
0.4912

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-30.80 kcal/mol
Thermodynamic ensemble
Free energy: -33.94 kcal/mol
Frequency: 0.0062
Diversity: 43.70
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.((((((.((((.(((.......((((....((...(((((((((((((((........))))))))......)))))))...))..)))).......)))))).).)))))).
Thermodynamic Ensemble Prediction
,(((((({((,{,(({{{.({..{(({....{{..,{((({{{{||{(((,{.{{{{{{,,,,))))}}.}}})}}}}}}.,,||..}},,..,))).))))),,..)))))),
Forensic Context

A study in humans demonstrated that the mir-765 is significantly upregulated in denatured dermis from deep partial-thickness burn patients compared to paired normal skin, with a 36.22-fold increase measured by microarray and validated via qRT-PCR [Liang et al. DOI:10.1016/j.burns.2011.10.014]. This biomarker was also found to be upregulated in burn hypertrophic scar tissue versus normal skin in a comprehensive review of human miRNA expression post-burn [Siu et al. DOI:10.1111/wrr.13100]. A meta-analysis of human studies demonstrated that the mir-765 is detected in substantial plasma quantities in severe TBI patients and has high diagnostic value [Zhou et al. DOI:10.7150/ijms.48214].