Basic Information
Symbol
hsa-miR-765
RNA class
miRNA
mature miRNA
Alias
hsa-miR-765
MIR765
MicroRNA 765
Sequence & Structure
Secondary Structure
Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-30.80 kcal/mol
Thermodynamic ensemble
Free energy:
-33.94 kcal/mol
Frequency:
0.0062
Diversity:
43.70
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.((((((.((((.(((.......((((....((...(((((((((((((((........))))))))......)))))))...))..)))).......)))))).).)))))).
Thermodynamic Ensemble Prediction
,(((((({((,{,(({{{.({..{(({....{{..,{((({{{{||{(((,{.{{{{{{,,,,))))}}.}}})}}}}}}.,,||..}},,..,))).))))),,..)))))),
Forensic Context
A study in humans demonstrated that the miR-765 is significantly upregulated in denatured dermis from deep partial-thickness burn patients compared to paired normal skin, with a 36.22-fold increase measured by microarray and validated via qRT-PCR [Liang et al. DOI:10.1016/j.burns.2011.10.014]. This biomarker was also found to be upregulated in burn hypertrophic scar tissue versus normal skin in a comprehensive review of human miRNA expression post-burn [Siu et al. DOI:10.1111/wrr.13100]. A meta-analysis of human studies demonstrated that the miR-765 is detected in substantial plasma quantities in severe TBI patients and has high diagnostic value [Zhou et al. DOI:10.7150/ijms.48214].