Basic Information

Symbol
hsa-mir-770
RNA class
miRNA miRNA hairpin
Alias
MIR770 MicroRNA 770 Hsa-MiR-770-5p Hsa-Mir-770 MIRN770 Hsa-Mir-770_pre MIMAT0003948 MI0005118
Location (GRCh38)
1:93846832-93846911
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification Drug abuse diagnoses Forensic psychiatry evaluation
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-770
Sequence length
98 nt
GC content
0.6531

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-55.80 kcal/mol
Thermodynamic ensemble
Free energy: -58.97 kcal/mol
Frequency: 0.0058
Diversity: 16.59
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((((.(((((..(((.((((((((((((..((((((.((.((((((......)))))))))))))))))))))))))).))).)))))..))))).
Thermodynamic Ensemble Prediction
,(((((.(((({{.(((,({((((((((((,.{((((({((.((((((......)))))))))))))))))))))))))).))).)))))..))))),
Forensic Context

A review of human studies identified 197 miRNAs associated with wound healing, burn wound healing, and scarring, with specific expression patterns in human skin tissue and cells post-burn and in hypertrophic scars [Siu et al. DOI:10.1111/wrr.13100]. A systematic review of the literature indicates that the mir-770 is downregulated by cocaine exposure in humans and animal models, where it is involved in the modulation of metabolic processes [Occhipinti et al. DOI:10.3390/Ijms242317122]. Furthermore, the mir-770 is decreased in human blood by the antidepressant escitalopram, demonstrating its modulation by psychotropic treatment [Miguel et al. DOI:10.1089/Ars.2017.7175].