Forensic Context

A review of human studies identified 197 miRNAs associated with wound healing, burn wound healing, and scarring, with specific dysregulation patterns observed in human skin tissue and cell lines post-thermal injury [Siu et al. DOI:10.1111/wrr.13100]. A study in mice demonstrated that the miR-802 is a predictive biomarker for survival, where high levels at day 2 were associated with reduced survival in C57Bl/6 mice and it was associated with TGF-β/SMAD signaling [Rogers et al. DOI: 10.1371/journal.pone.0232411]. In non-human primates, the miR-802 was used as a feature in a survival prediction model at Day 6, contributing to the forecasting of mortality following thoracic irradiation [May et al. DOI: 10.1038/s41598-022-16316-x].