Basic Information

Symbol
hsa-mir-873
RNA class
miRNA miRNA hairpin
Alias
MIR873 MicroRNA 873 Hsa-MiR-873-3p Hsa-MiR-873-5p Hsa-Mir-873 MIRN873 Hsa-Mir-873-V1_pre Hsa-Mir-873-V2_pre MIMAT0022717 MIMAT0004953 MI0005564 Mir-873
Location (GRCh38)
X:145996669-145996743
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Sudden cardiac death diagnosis Other applications
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-873
Sequence length
77 nt
GC content
0.4675

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-32.00 kcal/mol
Thermodynamic ensemble
Free energy: -33.09 kcal/mol
Frequency: 0.1711
Diversity: 9.19
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((.(..(((.(.(((((((((.((((((((.((.......)).)))))))).))))))))).).)))..).)))..
Thermodynamic Ensemble Prediction
{((,(..{((.(.(((((((((.((((((((.((.......)).)))))))).))))))))).).))}..).)))..
Forensic Context

A study in humans demonstrated that plasma-derived exosomes from severe trauma patients exhibited significant downregulation of 60 miRNAs and upregulation of 3 miRNAs compared to operative controls, with 12 of the downregulated miRNAs having a direct role in hematopoiesis regulation [Munley et al. DOI:10.1097/TA.0000000000004225]. In a separate human study, a competing endogenous RNA regulatory network for sepsis prognosis was constructed, identifying 26 miRNAs, including the mir-873, as connecting nodes between four core circRNAs and two core mRNAs (GSPT1 and NPRL3) [Chen et al. DOI:10.1038/s41598-024-78502-3]. A study in rats demonstrated that the mir-873 is a long non-coding RNA involved in myocardial ischemia-reperfusion injury by targeting miR-873 and suppressing RIPK1/RIPK3 [Lin et al. DOI:10.1186/s12867-018-0113-8]. In non-human primates, miR-873 was identified as a serum miRNA feature used in a Day 15 three-group survival prediction model following thoracic irradiation [May et al. DOI:10.1038/s41598-022-16316-x].