Basic Information

Symbol
hsa-mir-1298
RNA class
miRNA miRNA hairpin
Alias
MIR1298 MicroRNA 1298 Hsa-Mir-1298 Hsa-MiR-1298-5p MIRN1298 Hsa-Mir-1298_pre Hsa-MiR-1298-3p MIMAT0026641 MIMAT0005800 MI0003938
Location (GRCh38)
3:125790404-125790552
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Tissue/body fluid identification
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-1298
Sequence length
112 nt
GC content
0.4107

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-47.20 kcal/mol
Thermodynamic ensemble
Free energy: -47.78 kcal/mol
Frequency: 0.3918
Diversity: 2.02
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
....(((((((.(((((((((.((((.((((((((((((((((((((........)))))))......))))))))))))).)))).))))))))).)))))))........
Thermodynamic Ensemble Prediction
....(((((((.(((((((((.((((.((((((((((((((((((((......,.)))))))......))))))))))))).)))).))))))))).)))))))........
Forensic Context

A study in human postmortem serum demonstrated that exosomal hsa-miR-1298-3p was significantly downregulated (3.29-fold) in acute myocardial infarction cases compared to hemorrhagic shock controls [Kanno et al. DOI:10.1007/S00414-022-02913-Y]. A separate review of human skin tissue reported that hsa-miR-1298-5p was downregulated in venous ulcers compared to normal skin and acute wounds [Siu et al. DOI:10.1111/wrr.13100]. The mir-1298 is a microRNA with demonstrated diagnostic and therapeutic roles in diabetic erectile dysfunction (ED) in rat models, where it is downregulated in penile tissue and its miR-1298/B4GalT1 axis may function in stem cell therapy for ED [Song et al. DOI:10.3389/fendo.2022.1034043]. This biomarker is also identified as a potential forensic evidence marker, as it can differentiate venous blood from other body fluids [Liu et al. DOI:10.1016/j.ccr.2025.216644].