Forensic Context

A study in humans demonstrated that plasma-derived exosomes from trauma patients exhibited significant downregulation of the miR-873-5p compared to operative controls, with this miRNA being associated with the mitigation of neuroinflammation in spinal cord injury or traumatic brain injury [Munley et al. DOI:10.1097/TA.0000000000004225]. Furthermore, a separate review highlighted that the miR-873-5p is part of a regulatory axis, where circC6orf132 promotes gastric cancer progression under hypoxic conditions via a miR-873-5p/PRKAA1 mechanism [Huang et al. DOI:10.3390/cells11091381].