Forensic Context

A study in humans demonstrated that hsa-miR-874-3p is a potential biomarker for acute myocardial infarction, as it was significantly increased (3.319-fold) in plasma-derived exosomes from the myocardial infarction group compared to the control group in next-generation sequencing analysis [Kim et al. DOI:10.3390/ijms25179619]. In rats, miR-874 was highly upregulated (119-fold) in cerebral cortex tissue after traumatic brain injury under normothermic conditions at 7 hours, but its levels were lower in hypothermia-treated animals, with qRT-PCR and in situ hybridization confirming its temperature-sensitive response to injury [Truettner et al. DOI:10.1038/jcbfm.2011.33]. In a mouse model, the mir-874 was increased in TBI animals that did not exercise, whereas its expression was decreased in TBI animals that engaged in voluntary running, indicating its modulation by physical activity [Martinez & Peplow DOI:10.4103/1673-5374.219025].