Forensic Context

A study in humans demonstrated that hsa-miR-874-3p was significantly increased (3.319-fold) in plasma-derived exosomes from an acute myocardial infarction group compared to a control group in next-generation sequencing analysis, identifying it as a potential biomarker for postmortem diagnosis of acute myocardial infarction [Kim et al. DOI:10.3390/ijms25179619]. A study in rats demonstrated that the miR-874-3p is downregulated in diabetic erectile dysfunction (ED) penile tissue, where it binds to Nupr1 and inhibits the Nupr1/Chop-mediated pathway to exert an anti-apoptotic effect [Song et al. DOI:10.3389/fendo.2022.1034043].