Forensic Context

A study in humans analyzing postmortem plasma and pericardial fluid exosomes identified the miR-874-5p as a potential biomarker for acute myocardial infarction, showing a significant 3.319-fold increase in plasma-derived exosomes from the myocardial infarction group compared to controls via next-generation sequencing [Kim et al. DOI:10.3390/ijms25179619]. A study in mice demonstrated that the miR-874-5p was one of 20 selected miRNAs identified as differentially expressed in heart tissue exosomes following acute myocardial infarction, and its mimic significantly reduced hypoxic stress-induced cell death in primary cardiomyocytes and fibroblasts, indicating its potential as a therapeutic target [Jung et al. DOI:10.3390/biomedicines12020430].