Basic Information

Symbol
hsa-mir-877
RNA class
miRNA miRNA hairpin
Alias
MIR877 MicroRNA 877 Hsa-MiR-877-3p Hsa-MiR-877-5p Hsa-Mir-877 MIRN877 Hsa-Mir-877_pre MIMAT0004949 MIMAT0004950 MI0005561 MiRNA877 Mir-877
Location (GRCh38)
3:10394489-10394562
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-877
Sequence length
86 nt
GC content
0.6279

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-39.80 kcal/mol
Thermodynamic ensemble
Free energy: -40.65 kcal/mol
Frequency: 0.2509
Diversity: 3.20
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
...((((((..((.(.((((((((((.(.......((((((((((...)))))))))).).)))))))))).).))))))))....
Thermodynamic Ensemble Prediction
...((((((..((.(.((((((((((.(,......,(((((((((...)))))))))).).)))))))))).).))))))))....
Forensic Context

A study in mice demonstrated that the mir-877 was down-regulated -2.78-fold in the hippocampus after traumatic brain injury at normal temperature and -2.33-fold under low-temperature conditions at 4 hours post-injury [Wang et al. DOI:10.1258/ebm.2012.012123]. A study in rats identified the mir-877 as a key biomarker of acute myocardial ischemia (AMI) via LASSO regression, with a diagnostic area under the curve (AUC) of 75% [Zhao et al. DOI:10.3390/cimb47110889].