Forensic Context

A study in mice demonstrated that the miR-877-5p was significantly induced in splenic monocytes 24 hours after burn injury according to microarray analysis, though this change was not confirmed by subsequent RT-qPCR validation [Liu et al. DOI:10.1111/iwj.14288]. A review of human studies identified numerous miRNAs dysregulated in burn and wound healing contexts, though the specific forensic application of the miR-877-5p was not detailed among the validated findings [Siu et al. DOI:10.1111/wrr.13100]. In a separate study on traumatic brain injury in mice, the miR-877-5p was found to be down-regulated in the hippocampus at 4 hours post-injury under both normal and low-temperature conditions [Wang et al. DOI:10.1258/ebm.2012.012123].