Forensic Context

A study in humans demonstrated that the mir-885 was downregulated in plasma at 48 hours post-injury in spinal cord injury patients compared to healthy controls using next-generation sequencing, though subsequent droplet digital PCR validation did not show a significant difference [Hörauf et al. DOI:10.3390/ijms262210954]. A study in rhesus macaques demonstrated that the mir-885 was identified as a common radiation response marker, being one of the ten most statistically significant miRNAs common to both genders and both radiation doses at any time point [May et al. DOI:10.1038/s41598-022-16316-x]. In a separate human forensic investigation, the mir-885 was found to be differentially expressed across multiple pairs of monozygotic twins, specifically being shared across three pairs as miR-885-3p and across two pairs as miR-885-5p, with its expression validated by microarray analysis [Xiao et al. DOI:10.1016/j.fsigen.2019.05.003].