Forensic Context

A study in human patients with coronary artery disease demonstrated that the miR-92a-1-5p was downregulated in whole blood of individuals experiencing recurrent myocardial infarction after percutaneous coronary intervention, with this differential expression remaining significant after false discovery rate correction, though it was not significantly different in plasma samples [Onuoha et al. DOI:10.1111/cts.13307]. Separately, research in cultured human aortic endothelial cells identified the miR-92a-1-5p as one of ten miRNA markers capable of differentiating unirradiated (0 Gy) samples from those exposed to ionizing radiation at a 72-hour post-exposure time point [Chopra et al. DOI:10.1038/s41598-022-24051-6]. A review summarizing research across humans, mice, rats, and non-human primates noted that the miR-92a-1-5p is expressed in erythrocytes, which affects levels of circulating miRNAs, and it was reported as down-regulated in human serum in the context of radiotherapy prognosis [Jia & Wang DOI:10.3389/fcell.2022.861451].