Forensic Context

A study in humans demonstrated that plasma-derived exosomes from severe trauma patients exhibit significant downregulation of 60 miRNAs and upregulation of 3 compared to operative controls, with 12 downregulated miRNAs, including the miR-92a-2-5p, having direct roles in hematopoiesis regulation [Munley et al. DOI:10.1097/TA.0000000000004225]. Another human study found that plasma miRNAs, including a subset of seven upregulated candidates, show good diagnostic accuracy for traumatic brain injury, with specific miRNAs like miR-3195 and miR-328-5p capable of distinguishing severe from mild/moderate injury [Qin et al. DOI:10.1371/journal.pone.0204051]. A study in humans demonstrated that the miR-92a-2-5p is differentially expressed between monozygotic twins, as microarray analysis of blood samples from 18 pairs of Han Chinese monozygotic twins identified it as a shared, differentially expressed microRNA across three twin pairs [Xiao et al. DOI:10.1016/j.fsigen.2019.05.003].