Forensic Context

A study in rats demonstrated that the miR-92b-3p is upregulated in the infralimbic prefrontal cortex following both 18-hour withdrawal and 4-week abstinence from escalated cocaine self-administration, with its expression changes being part of a broader miRNA landscape alteration in the cortico-accumbal pathway associated with addiction-related behaviors [Kumaresan et al. DOI:10.3390/Biomedicines11051368]. In a separate forensic investigation in rats, the miR-92b-3p was identified as the most significantly upregulated miRNA in skeletal muscle at a 24-hour postmortem interval, suggesting its potential role as a biomarker for PMI estimation [Guardado-Estrada et al. DOI:10.7717/peerj.15409]. A study in rats demonstrated that heroin exposure significantly altered miRNA profiles in specific brain regions, with the miR-92b-3p upregulated 1.74-fold in the hippocampus of heroin-addicted Wistar rats [Pence et al. DOI:10.1007/S00221-024-06972-Y].