Forensic Context

A study in human and mouse RNA samples demonstrated that the miR-93-5p exhibited stable expression levels with no significant changes in severely heat- or RNase-degraded samples compared to intact samples, as measured by both TaqMan-qPCR and droplet digital PCR [Li et al. DOI:10.1016/j.forsciint.2024.111976]. Furthermore, a meta-analysis of human mild traumatic brain injury (mTBI) patients identified the miR-93-5p as a diagnostic biomarker upregulated in serum, targeting 2540 genes and belonging to specific signaling pathways such as MAPK, TGF-β, and PI3K/AKT [Matyasova et al. DOI:10.4149/gpb_2021038]. In a separate study on human body fluid identification, the miR-93-5p was evaluated as a candidate reference gene for data normalization across five body fluids [Li et al. DOI:10.1016/j.fsigen.2024.103180].