Forensic Context

A study in humans demonstrated that plasma-derived exosomes from severe trauma patients exhibited significant downregulation of the miR-935 compared to operative controls, and this downregulation was specifically linked to pathways involved in hematopoiesis and immune function regulation, such as macrophage polarization [Munley et al. DOI:10.1097/TA.0000000000004225]. A systematic review of animal and human studies found that the miR-935 was upregulated in the testes of diabetic rats and in the serum of type 2 diabetic humans, where it was associated with Leydig cell apoptosis, reduced testosterone, and diabetes-induced testicular damage and steroidogenesis destruction [Latifi et al. DOI:10.1007/s11033-024-10197-1].