Basic Information

Symbol
hsa-mir-939
RNA class
miRNA miRNA hairpin
Alias
MIR939 MicroRNA 939 Hsa-MiR-939-5p Hsa-Mir-939 MIRN939 Hsa-MiR-939-3p MIMAT0022939 MIMAT0004982 MI0005761 Mir-939
Location (GRCh38)
8:144394149-144394230
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-939
Sequence length
82 nt
GC content
0.7439

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-56.80 kcal/mol
Thermodynamic ensemble
Free energy: -57.87 kcal/mol
Frequency: 0.1748
Diversity: 6.93
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.((((...((((.(((((((((.(((((.((((((..(((....)))..))))))))))).))))))))).))))..)))).
Thermodynamic Ensemble Prediction
.((((.,.((((.(((((((((.((((({(,((((..(((....)))..))))))))))).))))))))).)))),.)))).
Forensic Context

A study in human postmortem cardiac tissue demonstrated that the mir-939-5p was significantly upregulated in both infarcted and non-infarcted regions of myocardial infarction hearts compared to healthy controls, with its strongest expression in the infarcted regions [Wilmes et al. DOI:10.1016/J.Forsciint.2023.111892]. In contrast, a separate study in living human patients with acute myocardial infarction found that circulating levels of the mir-939-5p were significantly downregulated in plasma compared to non-AMI controls and were identified among the top differentially expressed miRNAs with diagnostic potential [Zhong et al. DOI:10.1002/jcla.23099].