Basic Information

Symbol
hsa-mir-130a
RNA class
miRNA miRNA hairpin
Alias
MIR130A MicroRNA 130a Hsa-MiR-130a-3p Hsa-Mir-130a MIRN130A Hsa-Mir-130-P1c_pre Hsa-MiR-130a-5p MIMAT0004593 MIMAT0000425 MiRNA130A MI0000448 Mir-130a
Location (GRCh38)
X:53557192-53557274
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Wound age identification Other applications
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-130a
Sequence length
89 nt
GC content
0.5056

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-42.20 kcal/mol
Thermodynamic ensemble
Free energy: -43.12 kcal/mol
Frequency: 0.2251
Diversity: 6.89
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
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Forensic Context

A study in humans identified the mir-130a as down-regulated in peripheral blood mononuclear cells of chronic benzene poisoning patients compared to healthy controls, with this differential expression integrated into a broader miRNA profile associated with key cancer-related pathways [Bai et al. DOI:10.1016/J.Yexmp.2014.04.011]. A systematic review further catalogued the mir-130a as a down-regulated biomarker for chronic benzene poisoning, noting that the field of miRNA exposure biomarkers remains in its infancy and requires further validation [Kotsyfakis et al. DOI:10.1080/1354750X.2019.1652348]. A study in human postmortem brain tissue demonstrated that the mir-130a is upregulated in traumatic brain injury (TBI) cases compared to non-traumatic controls and its expression is significantly higher in cases with short (<1 day) and middle (1–7 days) survival times, indicating its role as a diagnostic and prognostic biomarker correlating with injury timing [Consalvo et al. DOI:10.3390/ijms25179539]. In a murine model of paraquat-induced lung injury, the mir-130a was downregulated in alveolar epithelial cells and its target genes, including BCL2 and TGFBR1, are involved in regulating oxidative stress and apoptosis pathways [Zhao et al. DOI:10.2131/Jts.45.423].