Forensic Context

A study in human postmortem cardiac tissue demonstrated that the miR-939-5p was significantly upregulated in both infarcted and non-infarcted regions of myocardial infarction hearts compared to healthy controls, with its strongest expression in the infarcted regions [Wilmes et al. DOI:10.1016/J.Forsciint.2023.111892]. In contrast, a separate study in living human patients with acute myocardial infarction found that circulating levels of the miR-939-5p were significantly downregulated in plasma compared to non-AMI controls and were identified among the top differentially expressed miRNAs with diagnostic potential [Zhong et al. DOI:10.1002/jcla.23099].