Forensic Context

A study in humans demonstrated that the miR-943 is strongly over-expressed in semen relative to other forensically relevant body fluids, as confirmed by quantitative RT-PCR validation [Zubakov et al. DOI:10.1007/s00414-009-0402-3]. A review further notes that miRNAs, including the miR-943, are used for body fluid identification via mathematical models like discriminant analysis, with RNA-based methods being robust for routine forensic use [Courts et al. DOI:10.3238/arztebl.m2024.0051]. A review of human forensic miRNA profiling literature notes that the miR-943 was identified as a potential biomarker for semen identification [Glynn DOI:10.1261/rna.072173.119]. In a separate study, the miR-943 was reported as differentially expressed in semen, contributing to the successful identification and discrimination of body fluids using miRNA assays [Courts and Madea DOI:10.1016/J.Forsciint.2010.07.002].