Basic Information

Symbol
hsa-mir-98
RNA class
miRNA miRNA hairpin
Alias
MIR98 MicroRNA 98 Hsa-MiR-98-5p Hsa-Mir-98 MIRLET7L MicroRNA Let-7l Hsa-MiR-98-3p MIRN98 Hsa-Let-7-P2b3_pre MIMAT0022842 MIMAT0000096 MI0000100 MiR-98
Location (GRCh38)
X:53556223-53556341
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification Cause of death analysis Sudden death from CNS diseases Other applications
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-98
Sequence length
119 nt
GC content
0.4286

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-56.70 kcal/mol
Thermodynamic ensemble
Free energy: -57.94 kcal/mol
Frequency: 0.1335
Diversity: 5.72
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.((((..((((((((((((((.(((((((((((((((((.((((((((((...........)))))).........)))).))))))))))))))))))))))))))).)))).)))).
Thermodynamic Ensemble Prediction
.((((..((((((((((((((.(((((((((((((((((.((((((((((...........)))))}........,)))).))))))))))))))))))))))))))).)))).)))).
Forensic Context

A review of human studies identified 197 miRNAs associated with wound healing, burn wound healing, and scarring, with the mir-98 being downregulated in hypertrophic scar tissue compared to normal skin [Siu et al. DOI:10.1111/wrr.13100]. In a separate postmortem investigation of human myocardial tissue, the mir-98 was found to be upregulated in the hearts of deceased patients with sepsis compared to non-septic controls [Pasi et al. DOI:10.1038/s41598-024-81114-6]. A study in rats demonstrated that the mir-98 is a cold-responsive miRNA, with rno-miR-98-5p expression decreasing significantly in serum and increasing significantly in liver following a 12-hour exposure to 4°C [Zhen et al. DOI:10.1016/j.jtherbio.2017.03.005]. In the context of spinal cord injury in rodent models, miR-98 is noted for its role in inflammation, where it functions to silence the anti-inflammatory cytokine IL-10 [Nieto-Diaz et al. DOI:10.3389/fncel.2014.00053].