Basic Information

Symbol
hsa-mir-99a
RNA class
miRNA miRNA hairpin
Alias
MIR99A MicroRNA 99a Hsa-MiR-99a-3p Hsa-MiR-99a-5p Hsa-Mir-99a MIRN99A Hsa-Mir-10-P2c_pre MIMAT0000097 MIMAT0004511 MI0000101 Mir-99a
Location (GRCh38)
16:14303967-14304049
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification Sudden cardiac death diagnosis Cause of death analysis
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-99a
Sequence length
81 nt
GC content
0.5309

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-39.50 kcal/mol
Thermodynamic ensemble
Free energy: -40.71 kcal/mol
Frequency: 0.1408
Diversity: 6.35
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
..((((((((((.(((((((((..(((.(((((({({......,,)))))))).)))..))))))))).))))))))))..
Forensic Context

A review of human studies found that the mir-99a is downregulated 24 hours post-injury in skin wounds compared to unwounded skin [Siu et al. DOI:10.1111/wrr.13100]. A study in rats demonstrated that the mir-99a was significantly upregulated in myocardial tissues following a 15% third-degree burn injury and was validated as a potential biomarker for myocardial damage via qRT-PCR [Guo et al. DOI:10.1080/09168451.2020.1807901].