A study in humans identified the miR-99a-5p as downregulated 24 hours post-injury in skin wounds compared to unwounded skin [Siu et al. DOI:10.1111/wrr.13100]. A study in rats demonstrated that the miR-99a-5p was upregulated 1.78-fold in the hippocampus and downregulated 0.483193-fold in skeletal muscle following burn trauma [Zhang et al. DOI:10.5505/tjtes.2015.80707], while another study in rats found it was upregulated 1.78-fold in the hippocampus of heroin-addicted animals [Pence et al. DOI:10.1007/S00221-024-06972-Y].