Basic Information

Symbol
hsa-mir-99b
RNA class
miRNA miRNA hairpin
Alias
MIR99B MicroRNA 99b Hsa-MiR-99b-3p Hsa-MiR-99b-5p Hsa-Mir-99b MIRN99B Hsa-Mir-10-P2b_pre MIMAT0004678 MIMAT0000689 MI0000746 Mir-99b
Location (GRCh38)
19:51692612-51692681
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification Drug abuse diagnoses Cause of death analysis
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-99b
Sequence length
70 nt
GC content
0.6714

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-29.40 kcal/mol
Thermodynamic ensemble
Free energy: -30.60 kcal/mol
Frequency: 0.1424
Diversity: 6.12
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
(((((..(((((((((.{(((.((((.(,(((....))).)...)))).))).})))))))))..)))))
Forensic Context

A review of human studies identified 197 miRNAs associated with wound healing, burn wound healing, and scarring, with specific dysregulation patterns observed in human skin tissue and cell lines post-thermal injury [Siu et al. DOI:10.1111/wrr.13100]. A study in mice demonstrated that methamphetamine-induced locomotor sensitization involves significant downregulation of the mir-99b in the nucleus accumbens, alongside other miRNAs, with precursor levels unchanged or upregulated, indicating post-transcriptional dysregulation via Ago2 and Dicer1 in miRNA biogenesis [Liu et al. DOI:10.1111/Adb.12616]. In a rat model of whole thorax irradiation, next-generation sequencing and RT-qPCR analysis of whole blood identified specific miRNAs as candidate biomarkers for radiation injury, though the mir-99b did not show significant changes between irradiated and control animals at the studied time points [Gao et al. DOI:10.1038/srep44132].