Forensic Context

A review of human studies identified 197 miRNAs associated with wound healing, burn wound healing, and scarring, with specific expression patterns validated in human skin tissue samples and cell lines using qRT-PCR, microarrays, and next-generation sequencing [Siu et al. DOI:10.1111/wrr.13100]. A study in mice demonstrated that chronic methamphetamine exposure significantly alters miRNA expression in the nucleus accumbens, with miR-99b-3p identified as one of 45 known METH-responsive miRNAs through sequencing analysis [Zhu et al. DOI:10.002/jnr.23605]. Further computational analysis in a separate mouse model identified the miR-99b-3p as a potential Dicer1-targeting miRNA among a set previously reported to be downregulated by METH, suggesting its involvement in miRNA biogenesis pathways associated with addiction [Liu et al. DOI:10.1111/Adb.12616].