Forensic Context

A study in mice (Mus musculus) demonstrated that the mir-130b (mmu-miR-130b-5p) in peripheral blood leukocytes showed a positive linear correlation with radiation dose at both 24 and 48 hours after irradiation, with validation by RT-qPCR confirming its good correlation as a potential biological dosimeter for acute radiation injury [Li et al. DOI:10.1177/15593258221123679]. In a porcine model (Sus scrofa) of spinal cord injury, serum miR-130b showed high diagnostic accuracy (AUC = 0.95) for differentiating severe from moderate injury severities at early time points post-injury [Tigchelaar et al. DOI:10.1038/s41598-017-01299-x]. A systematic review of animal and clinical studies identified the mir-130b as a potential biomarker for diabetes-induced erectile dysfunction, with its reduction documented in the serum of diabetic patients with this condition [Latifi et al. DOI:10.1007/s11033-024-10197-1].