Basic Information

Symbol
hsa-mir-1307
RNA class
miRNA miRNA hairpin
Alias
MIR1307 MicroRNA 1307 Hsa-MiR-1307-3p Hsa-MiR-1307-5p Hsa-Mir-1307 MIRN1307 Hsa-Mir-1307_pre MIMAT0005951 MIMAT0022727 MI0006444 Mir-1307
Location (GRCh38)
10:103394253-103394401
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Forensic psychiatry evaluation Other applications
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-1307
Sequence length
149 nt
GC content
0.5638

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-54.80 kcal/mol
Thermodynamic ensemble
Free energy: -56.26 kcal/mol
Frequency: 0.0942
Diversity: 10.00
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((((.(((..(((((((((..(((.((((((((.(.(((.(((((((.((.((.((((.(((..((......))..))).)))))).))..))))))).))).).))))))))...)))...))...)))))))...))).)))))..
Thermodynamic Ensemble Prediction
(((((.(((..(((((((({..(((.((((((((.(.(((.(((((((.((.((.((((.(((..((......))..))).)))))).))..))))))).))).).))))))))...)))...)}...)))))))...))).)))))..
Forensic Context

A study in young human patients with acute coronary syndrome (ACS) identified the mir-1307 as down-regulated in patients with ST-segment elevated myocardial infarction (STEMI) via small RNA sequencing, though this differential expression was not validated by subsequent qRT-PCR [Tong et al. DOI:10.3390/ijms19051467]. Separately, research in human cells demonstrated that the mir-1307 is upregulated following ionizing radiation exposure, showing increased expression in human lymphoblastoid AHH-1 cells and in ex vivo irradiated human peripheral blood lymphocytes at 24 hours post-irradiation [Song et al. DOI:10.3390/life10120361]. A separate review of human postmortem brain tissue reported that the mir-1307 is downregulated in the amygdala of subjects with schizophrenia and is located on a locus associated with a schizophrenia risk allele [Yoshino & Dwivedi DOI:10.3389/fpsyt.2020.543893].