Basic Information

Symbol
hsa-mir-1-2
RNA class
miRNA miRNA hairpin
Alias
MIR1-2 MicroRNA 1-2 Hsa-MiR-1-3p Hsa-Mir-1-2 MIRN1-2 Hsa-Mir-1-P1_pre MIMAT0000416 MI0000437 MiRNA1-2 Mir-1-2
Location (GRCh38)
18:21829004-21829088
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-1-2
Sequence length
85 nt
GC content
0.3412

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-36.00 kcal/mol
Thermodynamic ensemble
Free energy: -36.99 kcal/mol
Frequency: 0.2017
Diversity: 4.77
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
.((((((.(((((((((((((((((((((..(((((.,,........}..))))).))))))))))))))))))))).)))))).
Forensic Context

A study in Wistar rats demonstrated that the mir-1-2 was significantly downregulated in skeletal muscle following burn trauma, with a fold change of 0.273701, identifying it as a potential biomarker for muscle wasting [Zhang et al. DOI:10.5505/tjtes.2015.80707]. In human myocardial infarction, the mir-1-2 was downregulated in infarcted heart tissue compared to healthy adult hearts, and its expression was also reduced in fetal hearts, indicating its involvement in cardiac pathology and development [Boštjančič et al. DOI:10.1159/000268088].