Basic Information

Symbol
hsa-mir-132
RNA class
miRNA miRNA hairpin
Alias
MIR132 MicroRNA 132 Hsa-MiR-132-5p Hsa-MiR-132-3p Hsa-Mir-132 MIRN132 Hsa-Mir-132-P1_pre MIMAT0004594 MIMAT0000426 MI0000449 MiRNA132 Mir-132
Location (GRCh38)
17:2049908-2050008
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-132
Sequence length
101 nt
GC content
0.6535

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-46.30 kcal/mol
Thermodynamic ensemble
Free energy: -47.65 kcal/mol
Frequency: 0.1120
Diversity: 4.35
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((....((((((.(.((((.(((((((((...((((((((((..(....)....))))))))))...))))))))).)))).).)).))))....))).
Thermodynamic Ensemble Prediction
.(((....((((((.(.((((.(((((((((.,.((((((((((.,{,...},...)))))))))).,.))))))))).)))).).)).))))....))).
Forensic Context

A study in mice demonstrated that neuronal activity rapidly induces transcription of the CREB-regulated microRNA-132 in vivo, with its primary transcript (pri-miR-132) showing a robust, rapid, and transient increase following pilocarpine-induced seizures, cocaine injection, odorant exposure, and contextual fear conditioning, peaking at 45 minutes and returning to baseline within 2 hours [Nudelman et al. DOI:10.1002/Hipo.20646]. Research in rats established that specific overexpression of the mir-132 in neural stem cells of the adult dentate gyrus potentiates the acquisition and resists the extinction of morphine self-administration, indicating its involvement in opioid addiction [Jia et al. DOI:10.1007/S12264-019-00338-Z].