Forensic Context

A study in humans demonstrated that the miR-132-5p is upregulated in hypertrophic scar tissue and its derived fibroblasts from burn patients compared to normal fibroblasts, and its expression is also increased in skin wounds at 1 and 7 days post-injury [Siu et al. DOI:10.1111/wrr.13100]. A study in rats demonstrated that the miR-132-5p was significantly upregulated in the left ventricle (2.61-fold at 0.1 mg/kg and 2.92-fold at 10 mg/kg isoproterenol) as early as one hour after β-adrenergic stimulation, which was confirmed by RT-PCR and associated with elevated plasma troponin-I levels indicating cardiac injury [Hosoya et al. DOI:10.1016/J.Legalmed.2024.102475]. In a separate study in mice, the miR-132-5p was found to be upregulated in the hippocampus following chronic alcohol exposure and was identified as a regulator of the downregulated gene EGR1 within a constructed miRNA-mRNA network associated with neurodegeneration [Du et al. DOI:10.3389/Fphar.2024.1377501].