Basic Information

Symbol
hsa-mir-133b
RNA class
miRNA miRNA hairpin
Alias
MIR133B MicroRNA 133b Hsa-Mir-133b Hsa-MiR-133b MIRN133B Hsa-Mir-133-P2-V1_pre Hsa-Mir-133-P2-V2_pre MIMAT0000770 MiRNA133B MI0000822 Mir-133b
Location (GRCh38)
6:52148923-52149041
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-133b
Sequence length
119 nt
GC content
0.5714

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-47.80 kcal/mol
Thermodynamic ensemble
Free energy: -50.09 kcal/mol
Frequency: 0.5564
Diversity: 0.86
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
..............(((((((((((.((((((((..((.((.((((((.((.((((...)))))))))))).)).))..)))))))).)))))))..))))....(((.....)))...
Thermodynamic Ensemble Prediction
.{{{..,.,,....(((((((((((.((((((((..((.((.((((((.((.((({...)))))))))))).)).))..)))))))).)))))))..))))....,{,.,,.})}),}.
Forensic Context

A study in human autopsy samples of infarcted heart tissue demonstrated that the mir-133b had similar expression levels in myocardial infarction compared to healthy adult hearts, but was downregulated in fetal hearts and in a subset of MI patients with documented ventricular fibrillation/ventricular tachycardia [Boštjančič et al. DOI:10.1159/000268088]. A study in Wistar rats demonstrated that the mir-133b was significantly downregulated (fold change 0.365804) in tibialis anterior muscles at day 3 post-burn injury compared to sham-burn controls, identifying it as a potential biomarker for skeletal muscle wasting in burn trauma [Zhang et al. DOI:10.5505/tjtes.2015.80707].