Basic Information
Symbol
hsa-miR-133b
RNA class
miRNA
mature miRNA
Alias
hsa-miR-133b
MIR133B
MicroRNA 133b
Location (GRCh38)
-
Forensic tag(s)
Sudden cardiac death diagnosis
Cause of death analysis
External database
Sequence & Structure
Secondary Structure
Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-47.80 kcal/mol
Thermodynamic ensemble
Free energy:
-50.09 kcal/mol
Frequency:
0.5564
Diversity:
0.86
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
..............(((((((((((.((((((((..((.((.((((((.((.((((...)))))))))))).)).))..)))))))).)))))))..))))....(((.....)))...
Thermodynamic Ensemble Prediction
.{{{..,.,,....(((((((((((.((((((((..((.((.((((((.((.((({...)))))))))))).)).))..)))))))).)))))))..))))....,{,.,,.})}),}.
Forensic Context
A study in human autopsy samples of infarcted heart tissue demonstrated that the miR-133b had similar expression levels in myocardial infarction compared to healthy adult hearts, but was downregulated in fetal hearts and in a subset of MI patients with documented ventricular fibrillation/ventricular tachycardia [Boštjančič et al. DOI:10.1159/000268088]. A study in Wistar rats demonstrated that the miR-133b was significantly downregulated (fold change 0.365804) in tibialis anterior muscles at day 3 post-burn injury compared to sham-burn controls, identifying it as a potential biomarker for skeletal muscle wasting in burn trauma [Zhang et al. DOI:10.5505/tjtes.2015.80707].